刊首语

本周把自己一年多没更新的个人公众号(思考问题的熊)更新了一次，结果很快就有了五十多条留言。
很多人都在反馈自己过去三四年发生和经历的事情，很神奇的感受，看似没有交集但是却也没有断了联系。

不知道你有没有一个自己很久没有留意却突然发现还有人在关注的东西，不妨分享一下。

专业文献

The Bioinformatics Toolbox for circRNA Discovery and Analysis

Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent advances in sequencing technologies and bioinformatics tools have led directly to an ever-expanding field of types and biological functions of circRNAs. In parallel with technological developments, practical applications of circRNAs have arisen including their utilization as biomarkers of human disease. Currently, circRNA-associated bioinformatics tools can support projects including circRNA annotation, circRNA identification and network analysis of competing endogenous RNA (ceRNA). In this review, we collected about 100 circRNA-associated bioinformatics tools and summarized their current attributes and capabilities. We also performed network analysis and text mining on circRNA tool publications in order to reveal trends in their ongoing development.**

• PMID: 32103237
• DOI: 10.1093/bib/bbaa001

circRNA 发展历史  

circRNA 分析工具

Quality control and processing of nascent RNA profiling data

Experiments that profile nascent RNA are growing in popularity; however, there is no standard analysis pipeline to uniformly process the data and assess quality. Here, we introduce PEPPRO, a comprehensive, scalable workflow for GRO-seq, PRO-seq, and ChRO-seq data. PEPPRO produces uniform processed output...